The Titan 357 Automated Split-and-Combine Combinatorial Peptide Synthesizer utilizes the split-and-combine protocols developed by Furka, Lam, Hruby and Houghton to automatically prepare combinatorial libraries containing thousands to millions of compounds. Designing custom libraries is simple with the versatile, easy-to-use software. The user can create completely randomized peptide libraries or libraries of peptides with only a few randomized positions within the sequence. The number of mixtures in each split-and-combine step can range from 2 up to 36.

The Titan 357 Combinatorial Peptide Synthesizer can also be utilized as a parallel peptide synthesizer to prepare up to 36 separate peptides simultaneously. Gentle but efficient vortex mixing thoroughly mixes the resin in the thirty-six 10-mL reaction units of the reactor assembly. The delivery arm of the Model 357 accurately and precisely transfers reagents from any point on the worktable to assure reproducible, high quality products.

The reactor assembly of the Titan 357 Automated Split-and-Combine Combinatorial Peptide Synthesizer features a 500 mL reaction vessel that can be used to prepare larger quantities of a single peptide. Vortex mixing, nitrogen bubbling or a combination of both ensure complete mixing and optimum reactions.